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Dr. Paul Mazanec, MD
Gastroenterology* Age 66
Dr. Paul Mazanec, MD
5.0 (1 Ratings)
Dr. Paul Mazanec, MD is a Gastroenterologist in Simpsonville, SC.
Dr. Paul Mazanec, MD
5.0 (1 Ratings)

Dr. Paul Mazanec, MD

Gastroenterology* Age 66
Simpsonville, SC
Accepting new patients
41 years of experience
Dr. Paul Mazanec, MD is a Gastroenterologist in Simpsonville, SC.

About Dr. Paul Mazanec, MD

Dr. Mazanec graduated from Case Western Reserve University School of Medicine in 1985 and completed a residency at North Carolina Baptist Hospital. Dr. Paul Mazanec, MD is a Gastroenterologist in Simpsonville, SC and has 41 years experience. Dr. Mazanec has experience treating conditions like Constipation, Nausea, Gastroesophageal Reflux Disease (GERD), Abdominal Pain, Dysphagia, Gastroptosis, Diarrhea, Gas-Bloat Syndrome, Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD), Unexplained Weight Loss, Heartburn, Gastrointestinal Bleeding, Gastritis, Esophagitis, Noninfectious Gastroenteritis and Colitis, Reflux Esophagitis, Intestinal Diverticulosis, Vomiting Disorders, Barrett's Esophagus, Irritable Bowel Syndrome, Diaphragmatic and Hiatal Hernia and Hemorrhoids among other conditions at varying frequencies. Dr. Mazanec's office accepts new patients. Dr. Mazanec accepts multiple insurance plans.

Experience Check

Enter a condition or procedure
Constipation
Nausea
Gastroesophageal Reflux Disease (GERD)
Constipation
Nausea
  • View other providers who treat Nausea
Gastroesophageal Reflux Disease (GERD)
Abdominal Pain
Dysphagia
Gastroptosis
Diarrhea
  • View other providers who treat Diarrhea
Gas-Bloat Syndrome
Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD)
Unexplained Weight Loss
Heartburn
Gastrointestinal Bleeding
Gastritis
Esophagitis
Noninfectious Gastroenteritis and Colitis
Reflux Esophagitis
Intestinal Diverticulosis
Vomiting Disorders
Barrett's Esophagus
Irritable Bowel Syndrome
Diaphragmatic and Hiatal Hernia
Hemorrhoids
Colorectal Polyp
Anal or Rectal Pain
Duodenal Polypectomy
Endoscopy
Esophageal Motility Disorders
Duodenitis
Esophageal Varices
Inflammatory Bowel Disease
Intestinal Diverticulitis
Rigid Proctosigmoidoscopy
Flexible Sigmoidoscopy
Manometry
Colonoscopy
Cirrhosis
Colonoscopy, Proctosigmoidoscopy, and Sigmoidoscopy
Ulcerative Colitis
Anemia
  • View other providers who treat Anemia
Diffuse Esophageal Spasm
Intestinal Ulcer
Gastroparesis
Eosinophilic Esophagitis
Acute Gastritis
Gastrointestinal Malabsorption
Rectal Ulcer
Removal or Destruction of Rectal or Intestinal Tumor (incl. Colonoscopy, Proctosigmoidoscopy, Sigmoidoscopy and Control of Hemorrhage)
Duodenal Ulcer
Chronic Gastritis
Gallstones
Sigmoidoscopy
Crohn's Disease
Splenomegaly
Ascites
  • View other providers who treat Ascites
Gastric Ulcer
Vitamin_Deficiency
Pancreatitis
Liver Damage from Alcohol
Primary Biliary Cholangitis
Congenital Anomaly Intestine
Biliary Cirrhosis
Dehydration
Malnutrition
Familial Adenomatous Polyposis
Hypokalemia
Alcoholic Cirrhosis
Hepatitis C
Enteritis
Ileus
  • View other providers who treat Ileus
Alcoholic Fatty Liver
Alcoholic Hepatitis
All Types of Food Poisoning
Autoimmune Hepatitis
Barretts Esophagus with Dysplasia
Benign Neoplasm of the Digestive System
Bile Duct Obstruction
Boerhaave's Syndrome
Bowel Strangulation
Celiac Disease
Cholangitis
Colitis
  • View other providers who treat Colitis
Colon Cancer
Colon Disorders
Colon Polyp
Colorectal Cancer
Congenital Achalasia
Congenital Anomaly Esophagus
Copper Metabolism Disorders
Cyclical Vomiting
Duodenal Cancer
Dysentery
E. coli Food Poisoning
Ehlers-Danlos Syndrome
Esophageal Achalasia and Cardiospasm
Esophageal Dilation
Esophageal Diverticulum
Esophageal Ulcer
Food Allergy
Gastrointestinal Diseases
Gastrojejunal Ulcer
Hemochromatosis
Hepatitis
Hepatitis A
Hepatitis B
Hepatitis B - Immune Response
Hepatorenal Syndrome
Hernia
  • View other providers who treat Hernia
Hiatal Hernia
Indigestion
Infectious Diarrheal Disease
Intestinal Obstruction
Intestinal Prolapse
Lactose Intolerance
Liver Abscess
Mallory-Weiss Syndrome
Megacolon
Neoplasm of Gastrointestinal Tract
Pancreatic Pseudocyst
Pelvic Abscess
Peptic Ulcer
Pernicious Anemia
Pinworm
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Pouchitis
Primary Sclerosing Cholangitis
Proctoptosis
Pyloric Stenosis
Rectal Cancer
Rectal Prolapse
Retroperitoneum Cancer
Sclerosing Mesenteritis
Stomach Stenosis
Ulcer
  • View other providers who treat Ulcer
Upper Digestive Tract Cancer
Viral Enteritis
Viral Hepatitis
Visceroptosis
Vitamin B12 Anemia
Anoscopy
  • View other providers who treat Anoscopy
Capsule Endoscopy
Colon Cancer Screening
Colonoscopy With Polypectomy
Colorectal Cancer Screening
Endoscopic Polypectomy
Endoscopic Ultrasound
ERCP (Endoscopic Retrograde Cholangiopancreatography)
Esophageal Stenting
Esophagoscopy
Gallbladder Scan
Hemorrhoidectomy or Excision of Anal Tags
Hepatitis A Screening
Hepatitis B Virus Screening
Hepatitis C Virus Screening
Hepatitis Screening
Impedance Testing
Instrumental Diagnostic Evaluation for Dysphagia
Liver Biopsy
Liver Function Test
Percutaneous Edoscopic Gastrostomy (PEG)
pH Probe
  • View other providers who treat pH Probe
Screening Colonoscopy
Ultrasound, Endoanal
Ultrasound, Esophageal
VAP Lipid Testing
Wireless pH Testing

Accepted Insurance Plans

* Please verify this information when scheduling an appointment.
  • Medical Mutual of Ohio
  • HealthyBlue Advantage
  • Medicaid
  • Centene
  • National (BlueCard) PPO
  • Blue Card PPO
  • Curative EPO
    Curative PPO
    Curative PPO Plus

Where Dr. Paul Mazanec, MD Sees Patients

  1. 1 Office
    112A Hospital Dr, Simpsonville, SC 29681
  2. 2 Gastroenterology Associates PA
    125 Halton Rd Ste 200, Greenville, SC 29607
  3. 3 Piedmont Imaging Inc
    225 E Blackstock Rd, Spartanburg, SC 29301
  4. 4 Anesthesia Associates of the Upstate LLC
    200 Patewood Dr Ste B200, Greenville, SC 29615
    Monday
    08:00 - 17:00
    Tuesday
    08:00 - 17:00
    Wednesday
    08:00 - 17:00
    Thursday
    08:00 - 17:00
    Friday
    08:00 - 12:00

What Patients Say

Likelihood to recommend Dr. Mazanec
5.0
Based on 1 Reviews
5 Stars (1)
4 Stars (0)
3 Stars (0)
2 Stars (0)
1 Star (0)

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Patient Reviews
Mar 13, 2026
Dr. Mazanec and team were ready for me and I was in and out quickly. He saw me before and after the procedure.
— Mar 13, 2026
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Meet Dr. Paul Mazanec, MD

Specialties*
Gastroenterology
Specialties*
  • *Sharecare does not verify qualifications for medical specialties. Please verify your provider's specialty and qualifications directly with your provider and applicable medical board.
Common Questions and Answers
Responses are sourced directly from patients.
Does Dr. Mazanec communicate via email?
12 users said yes.
Yes
(12)
No
(3)
Does Dr. Mazanec offer telehealth services or virtual visits?
7 users said yes.
Yes
(7)
No
(3)
Does Dr. Mazanec offer an online patient portal?
16 users said yes.
Yes
(16)
No
(0)
Does Dr. Mazanec have free onsite parking?
20 users said yes.
Yes
(20)
No
(0)
Does Dr. Mazanec offer weekend visits?
3 users said yes.
Yes
(3)
No
(9)
Does Dr. Mazanec offer evening visits?
5 users said yes.
Yes
(5)
No
(7)
Does Dr. Mazanec specialize in working with children or adolescents?
No responses yet.
Yes
(0)
No
(0)
Does Dr. Mazanec specialize in working with seniors?
No responses yet.
Yes
(0)
No
(0)
Does Dr. Mazanec specialize in couples therapy?
No responses yet.
Yes
(0)
No
(0)
Does Dr. Mazanec specialize in working with LGBTQ+ community?
No responses yet.
Yes
(0)
No
(0)
Does Dr. Mazanec accept insurance?
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(0)
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FAQs About Dr. Mazanec's Practice

Find contact information here to make an appointment.

A list of accepted insurance providers is available on the Sharecare insurance check. It is always a good idea to verify your insurance when making an appointment.

New patients are generally accepted by Dr. Paul Mazanec, MD. To arrange an appointment, call the number on Dr. Mazanec's profile.

Dr. Mazanec frequently treats the following conditions: Constipation, Nausea, Gastroesophageal Reflux Disease (GERD), Abdominal Pain, Dysphagia, Gastroptosis, Diarrhea, Gas-Bloat Syndrome, Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD), Unexplained Weight Loss, Heartburn, Gastrointestinal Bleeding, Gastritis, Esophagitis, Noninfectious Gastroenteritis and Colitis, Reflux Esophagitis, Intestinal Diverticulosis, Vomiting Disorders, Barrett's Esophagus, Irritable Bowel Syndrome, Diaphragmatic and Hiatal Hernia and Hemorrhoids. See more on Sharecare.

Dr. Paul Mazanec, MD is affiliated with Prisma Health Greenville Memorial Hospital, St. Francis Downtown and Prisma Health Hillcrest Hospital.

Training & Medical Education
Medical Education
  • Case Western Reserve University School of Medicine
    1985
Medical Education
Residency Hospital
  • North Carolina Baptist Hospital
    1988
Residency Hospital
Fellowship Hospital
  • Medical University of South Carolina
    1978
Fellowship Hospital

Hospitals Where Dr. Paul Mazanec, MD Practices

  • Prisma Health Greenville Memorial Hospital

    701 Grove Rd, Greenville, SC

  • St. Francis Downtown

    1 Saint Francis Dr, Greenville, SC

  • Prisma Health Hillcrest Hospital

    729 SE Main St, Simpsonville, SC

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